Work Packages
Program Overview
Our grant addresses the gut microbiome which consists of microorganisms including bacteria, fungi, and viruses. Together, they form a community called the microbiota or microbiome, which differs from organ to organ and person to person. Scientists have shown that these microorganisms have important roles in maintaining human health, but they can also play a role in the development of disease – including cancer.
To meet this Grand Challenge, we are focusing on two parts. The first part is an atlas of the colorectal cancer microbiome, across time and space. The goal is to understand how genetics and lifestyle risks impact the development of the colon cancer microbiome, and how this microbiome varies in populations. We will also examine the location of the microbiome within the colon cancer—how the microbiome is connected to cancer, immune and other human cells.
The second part is to investigate what happens when we try to treat the microbiome. Here the interactions between the microbiome and the immune system will be studied, and we will assess how current colon cancer treatments affect the microbiome. We will also analyze innovative new treatments that either treat the colon cancer microbiome or replace it with a healthier microbiome.
We have assembled a unique international team of physicians, scientists, and patient advocates to address these important and challenging questions in six separate work packages. The members of our team have led the way in understanding the biology of colon cancer, in general, and the colon cancer microbiome. We believe that we are the right group, at the right time, to address these important questions.
Researchers from our team have discovered that unique populations of bacteria not found in the normal colon are present in colorectal cancers and pre cancers. These bacteria, also known as the colorectal cancer microbiota or microbiome, are found in cancers within the colon and in colon cancers that have spread, or metastasized, to other organs.
By the end of the project, we hope to have a greater understanding of the microbiota’s relationship and impact on the risk, diagnosis and spread of colorectal cancer. We also hope to identify novel treatment strategies by manipulating the microbiota, and to gain insight into the impact of the microbiota on treatment and survivorship in people with colorectal cancer.
Work Packages
WP1: The Microbiome in colorectal cancer risk
WP1: The Microbiome in colorectal cancer riskWe are analyzing the microbiome of 3000 bowel tumors, to determine the relationship between the...
WP 2: Epidemiological correlates of the colorectal cancer microbiome
WP2: Epidemiological correlates of the colorectal cancer microbiomeColorectal cancer (CRC) most often occurs sporadically (as compared to genetic...
WP3: Mapping the cellular distribution of the bowel cancer microbiome
WP3: Mapping the cellular distribution of the bowel cancer microbiomeWe hope to better understand the bacterial cells that make up the colorectal...
WP 4: Model systems to study the colorectal cancer microbiome
WP4: Model systems to study the colorectal cancer microbiomeThe Clevers lab has been using their human ‘mini-gut’ technology. These mini guts...
WP 5: The interplay between the microbiota and colorectal cancer treatments
WP5: The interplay between the microbiota and colorectal cancer treatmentsThe colon is the most densely populated microbial ecosystem on the planet,...
WP 6: Novel treatments involving microbiome modulation
WP6: Novel treatments involving microbiome modulationTwo bacteria that can live inside the human gut, Fusobacterium nucleatum (Fn) and...