The Optimisticc team is supported through the Cancer Grand Challenges initiative. Learn more here
The Optimisticc team is supported through the Cancer Grand Challenges initiative. Learn more here
In a new review in Cell Host & Microbe, Jens Puschhof and Cayetano Pleguezuelos-Manzano, from the lab of Hans Clevers, describe advances in co-culturing microbes with intestinal and colonic epithelia. Organoid and organ-on-a-chip platforms in particular are compared to each other and to related models to evaluate the suitability of each for recapitulating host-microbe interactions, a key challenge in understanding the role of the microbiome in colon cancer.
Dr. Caroline Young from Dr. Phil Quirke’s lab in Leeds gave the CL Oakley Lecture for the Pathological Society of Great Britain and Ireland and was awarded the Oakley lecture medal.
Though strong evidence suggests the gut microbiota contributes to colorectal cancer (CRC) onset and/or progression, there is no universal signature of a gut microbe or microbiota associated with the disease. The functional capability of gut communities could be more...
By 2030 colorectal cancer will be the leading cause of cancer deaths in individuals aged 20-49. Young-onset CRC differs from average age onset. Young-onset disease is often more aggressive, presents on the left side of the colon rather than the right, and often...
