The Optimisticc team is supported through the Cancer Grand Challenges initiative. Learn more here
The Optimisticc team is supported through the Cancer Grand Challenges initiative. Learn more here
In a new review in Cell Host & Microbe, Jens Puschhof and Cayetano Pleguezuelos-Manzano, from the lab of Hans Clevers, describe advances in co-culturing microbes with intestinal and colonic epithelia. Organoid and organ-on-a-chip platforms in particular are compared to each other and to related models to evaluate the suitability of each for recapitulating host-microbe interactions, a key challenge in understanding the role of the microbiome in colon cancer.
By 2030 colorectal cancer will be the leading cause of cancer deaths in individuals aged 20-49. Young-onset CRC differs from average age onset. Young-onset disease is often more aggressive, presents on the left side of the colon rather than the right, and often...
Most research in cancer microbiomes is carried out in European and North American patients. Patterns in low- and middle-income countries are often assumed based on results from richer countries, despite different diets, living conditions and cancer rates. We...
Congratulations to Tomotaka Ugai, an instructor from Shuji Ogino’s lab, on receiving a Scholar-in-Training Award for his upcoming presentation at the annual AACR meeting April 14-19, 2023, in Orlando, FL.
