Curtis Huttenhower, PhD
Phone:Harvard TH Chan School of Public Health Boston, Massachusetts
Department:Curtis Huttenhower,Investigator Team,Investigators,WP2
Professor of Computational Biology and Bioinformatics
Departments of Biostatistics and Immunology and Infectious Diseases
Associate Member, Broad Institute of MIT and Harvard
Co-director, Harvard Chan Microbiome in Public Health Center
Metatranscriptomics (abbreviated “MTX”) is a powerful method for measuring the gene expression (functional activity) of many members of a microbial community all at the same time by using shotgun DNA sequencing technology. In a recent review article, the Huttenhower Lab surveys the state-of-the-art in this rapidly growing field and make recommendations for incorporating MTX in microbiome studies. For example, what bioinformatics methods are most appropriate for analyzing MTX sequencing data, and how do they differ from traditional community DNA sequence analysis? The authors explore many questions in detail with examples from successful prior MTX studies of the human microbiome and beyond. The article provides a rich resource for scientists looking to get started in the field of MTX as well as a positive vision for the future of the field.