Work from Dr. Fiona Powrie’s group at University of Oxford has identified an interaction between the receptor for the immune molecule interleukin-22 (IL-22) and alterations of the KRAS gene, showing that they cooperate in promoting excessive proliferation of colon cancer cells. As KRAS mutations are present in almost half of all colorectal tumors and are poorly responsive to standard therapies, these results suggest that patients with a mutant KRAS and high IL-22 receptor levels may benefit from alternative strategies involving IL-22 modulation. This study is published in Clinical Cancer Research and is described in more detail in a University of Oxford press release.
Congratulations Dr. Caroline Young
Dr. Caroline Young from Dr. Phil Quirke’s lab in Leeds gave the CL Oakley Lecture for the Pathological Society of Great Britain and Ireland and was awarded the Oakley lecture medal.
