By 2030 colorectal cancer will be the leading cause of cancer deaths in individuals aged 20-49. Young-onset CRC differs from average age...
Kimmie Ng and Marios Giannakis publish a perspective “A Common Cancer at an Uncommon Age”
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From the Scientist
Henry Wood leads the first study to look at CRC patterns in low- and middle-income countries
Most research in cancer microbiomes is carried out in European and North American patients. Patterns in low- and middle-income countries are often...
Congratulations to Tomotaka Ugai
Congratulations to Tomotaka Ugai, an instructor from Shuji Ogino’s lab, on receiving a Scholar-in-Training Award for his upcoming presentation at...
Microbes are important in human health
Dr. Emma Allen-Vercoe: The Importance of Microbes to Human HealthIn a recent podcast by the Centre for Inquiry Canada, Emma Allen-Vercoe talks about...
Future Leaders Conference
OPTIMISTICC Trainees Attend CGC Future Leaders Conference in Barcelona From Nov. 2-4, 2022, 14 OPTIMISTICC trainees joined members of other Cancer...
Western Diet and CRC
In a recent publication Kota Arima and other OPTIMISTICC team members published a paper Western-Style Diet, pks Island-Carrying Escherichia coli,...
New review about colorectal cancer and the microbiome
In a recent review by Slater Clay and other OPTIMISTICC team members, titled Colorectal cancer: the facts in the case of the microbiota they review...
Metatranscriptomics (“MTX”) is a powerful method for measuring microbial gene expression
Metatranscriptomics (abbreviated "MTX") is a powerful method for measuring the gene expression (functional activity) of many members of a microbial...
BRAF mutation changes the characteristics of colorectal cancers in a mouse model
In a recent publication, the Sears lab showed that introduction of the BRAFV600E mutation into mice colonized with enterotoxigenic Bacteroides...
New Link Between Red Meat Consumption and CRC
The Giannakis and Ogino labs have published a new study in Cancer Discovery that describes a mutational signature associated...
Organoids and Organs on Chips and the Microbiome: A New Review
In a new review in Cell Host & Microbe, Jens Puschhof and Cayetano Pleguezuelos-Manzano, from the lab of Hans Clevers, describe advances in...
A microbiome signature for colorectal cancer
A collaboration of the Quirke and Huttenhower labs has led to the publication of two papers, in Clinical Cancer Research and Genome Medicine, that...
Allen-Vercoe group publishes book chapter on Fusobacteria.
Graduate students Avery Robinson and Jacob Wilde contributed to a book chapter with Emma Allen-Vercoe that covers many aspects of Fusobacteria...
Can we treat bowel cancer by targeting the bugs in our guts?
Bowel cancer Cancer refers to a collection of diseases in which some of the body’s cells divide uncontrollably and can spread to other parts of the...
IL-22 Pathway Identified as a New Target in Colon Cancers with Mutant KRAS
Work from Dr. Fiona Powrie’s group at University of Oxford has identified an interaction between the receptor for the immune...
Biomarker for Locally Advanced Rectal Cancer (LARC) Identified from the Gut Microbiome
A team led by VHIO Principal Investigator and OPTIMISTICC scientist Dr. Paolo Nuciforo has found an association between the persistence of...
Studying the CRC Microbiome in Mice and a Robogut
Fusobacterium nucleatum(Fn) is a common bacterial member of the human oral microbiome—and it is an opportunist. When Fn is found elsewhere in the...
