Cynthia Sears, MD
Phone:Johns Hopkins University School of Medicine and Bloomberg School of Public Health
Email:Medicine; Infectious Diseases; Immunology
Department:Cynthia Sears,Investigator Team,Investigators,WP1
Professor of Medicine, Oncology, and Molecular Microbiology & Immunology
In a recent publication, the Sears lab showed that introduction of the BRAFV600E mutation into mice colonized with enterotoxigenic Bacteroides fragilis (ETBF) leads to production of midcolon tumors with similarity to human BRAFV600E tumors and distinct from the ETBF-induced distal adenomas typical for this ETBF mouse model. In particular, the BRAFV600E tumors show sensitivity to anti-PD-L1 treatment, suggesting a line of investigation for improving immunotherapy treatment for colon cancer. Check out this blog, on the Cancer Grand Challenges website, where Cindy discusses this work and its implications.