The Optimisticc team is supported through the Cancer Grand Challenges initiative. Learn more here

BRAF mutation changes the characteristics of colorectal cancers in a mouse model

September 8, 2021

BRAF mutation changes the characteristics of colorectal cancers in a mouse model

September 8, 2021
;

In a recent publication, the Sears lab showed that introduction of the BRAFV600E mutation into mice colonized with enterotoxigenic Bacteroides fragilis (ETBF) leads to production of midcolon tumors with similarity to human BRAFV600E tumors and distinct from the ETBF-induced distal adenomas typical for this ETBF mouse model. In particular, the BRAFV600E tumors show sensitivity to anti-PD-L1 treatment, suggesting a line of investigation for improving immunotherapy treatment for colon cancer. Check out this blog, on the Cancer Grand Challenges website, where Cindy discusses this work and its implications.

Related Posts

Microbes are important in human health

Microbes are important in human health

Dr. Emma Allen-Vercoe: The Importance of Microbes to Human HealthIn a recent podcast by the Centre for Inquiry Canada, Emma Allen-Vercoe talks about the importance of microbiome research and how she became involved in the OPTIMISTICC project.

Future Leaders Conference

Future Leaders Conference

OPTIMISTICC Trainees Attend CGC Future Leaders Conference in Barcelona From Nov. 2-4, 2022, 14 OPTIMISTICC trainees joined members of other Cancer Grand Challenges Teams in Barcelona, Spain for the 2022 Future Leaders Conference. Drs. Caroline Young and Yasutoshi...

Importance of Patient Engagement in Research

Importance of Patient Engagement in Research

In a recent editorial Laura Porter discusses the importance of patient engagement in research in a publication titled The Importance of Patient Engagement to Improve Healthcare Research and Safety. She not only acknowledges the benefits but also the challenges of...

Optimisticc
Loading...