by john@redlineux.com | May 3, 2022 | Work Packages Advocacy
WP3: Mapping the cellular distribution of the bowel cancer microbiome We hope to better understand the bacterial cells that make up the colorectal cancer microbiome, and how they interact with human cancer cells. For example, what types of bacteria are found with the...
by john@redlineux.com | May 3, 2022 | Work Packages Advocacy
WP4: Model systems to study the colorectal cancer microbiome The Clevers lab has been using their human ‘mini-gut’ technology. These mini guts (a.k.a. intestinal organoids) are grown in a dish from healthy gut stem cells. They can be expanded...
by john@redlineux.com | May 2, 2022 | Work Packages Advocacy
WP5: The interplay between the microbiota and colorectal cancer treatments The colon is the most densely populated microbial ecosystem on the planet, containing several trillion microbial cells that produce 100-fold more gene products than our human cells...
by john@redlineux.com | May 1, 2022 | Work Packages Advocacy
WP6: Novel treatments involving microbiome modulation Two bacteria that can live inside the human gut, Fusobacterium nucleatum (Fn) and enterotoxigenic Bacteroides fragilis (ETBF), have been found to be related to the development of colorectal...
by john@redlineux.com | Sep 8, 2021 | From the Scientist, News
In a recent publication, the Sears lab showed that introduction of the BRAFV600E mutation into mice colonized with enterotoxigenic Bacteroides fragilis (ETBF) leads to production of midcolon tumors with similarity to human BRAFV600E tumors and distinct from the...
